Dissolved carbon dioxide sensors are in-line sensors for continuous monitoring of dissolved CO2 in biopharmaceutical applications and brewing processes. For bioprocessing, dissolved CO2 probes enable in situ CO2 monitoring in bioreactors for control of production and to help ensure accurate scale up and maximize yield. In brewing, a dissolved CO2 sensor can be used to monitor key quality attributes to ensure consistent mouth-feel.
This video explains how the CO2 sensors provide the real-time, continuous data necessary for allowing an efficient control strategy in mammalian cell culture processes, leading to improved process yield and final-product quality.
In situ CO2 sensors provide immediate and accurate feedback of CO2 accumulation, allowing you to quickly react to changes in dissolved CO2 concentration.
Dissolved CO2 sensors with Plug and Measure technology offer fast, error-free installation and commissioning. To minimize maintenance efforts these CO2 sensors have few replacement parts.
METTLER TOLEDO dissolved CO2 sensors are constructed using FDA-compliant materials to ensure all CO2 probes can withstand CIP procedures and are fully sterilizable either in situ or in an autoclave.
CO2 sensors with Intelligent Sensor Management (ISM) provide advanced diagnostics to improve sensor reliability. ISM helps avoid sensor failure and ensures maintenance is only performed when needed.
High dCO2 levels cause unwanted metabolic changes and lower productivity. A dissolved CO2 sensor allows for fast reaction to CO2 changes, which can increase cell growth rates by as much as 30%.
To speed up the membrane replacement process, brewery CO2 sensors from METTLER TOLEDO only require two parts for membrane replacement, and replacement can be done in 30 seconds.
These CO2 sensors keep count of sensor exposure to autoclave cycles, offer predictive sensor health diagnostics and keep records of calibration to help meet regulatory compliance requirements.
CO2 is an important metabolic indicator in bioprocessing applications. It impacts extracellular and intracellular pH and can directly and indirectly impact glycosylation patterns and molecule stability. Read more
The new ISM InPro 5000i CO2 sensor combines precise and reliable in-line measurement of dissolved CO2, with the performance benefits of Intelligent Sensor Management (ISM). Read more
InPro 5000(i) sensors are intended solely for in-line measurement of dissolved CO2 (carbon dioxide). Read more
InPro 5500i has been developed for in-line CO2 measurements in brewery and carbonated soft drink processes. The sensor utilizes the well-proven thermal conductivity method to determine CO2 in liquids. Read more
The construction of the InPro series employs leading edge technology and complies with safety regulations currently in force. Notwithstanding this, improper use could lead to hazards for the user or a third-party, and/or adverse effects on the plant or other equipment. Read more
The value of measuring and regulating dissolved CO2 levels in cell culture is rapidly growing in acceptance. Traditional methods of at-line and off-line CO2 measurements are common, but do not allow the necessary real-time monitoring that can result in process improvements. Read more
We support and service your measurement equipment through its entire life-cycle, from installation to preventive maintenance and calibration to equipment repair.
Dissolved carbon dioxide is the amount of CO2 present in water or another liquid. Carbon dioxide typically is encountered as a gas. Therefore, the in-line and on-line measurement of carbon dioxide in processes is a measurement of the pressure which the carbon dioxide applies either in the gas or in the liquid in which it is dissolved. Dissolved carbon dioxide can be measured using a METTLER TOLEDO dissolved CO2 sensor.
Dissolved carbon dioxide is measured with a dissolved carbon dioxide sensor designed by METTLER TOLEDO. Depending on the kind of application and the industry, the dissolved CO2 content is expressed in different units.
A dissolved carbon dioxide sensor is an analytical sensor that measures dissolved carbon dioxide. METTLER TOLEDO dissolved CO2 probes deliver precise, real-time data that increases understanding of critical fermentation, cell culture and brewing processes.
There are two primary types of CO2 sensor in the METTLER TOLEDO portfolio.
For bioreactors and pharmaceutical production, the InPro 5000i is a dissolved CO2 probe that provides real-time CO2 values based on the technology of the Severinghaus principle, which utilizes the correlation between dissolved carbon dioxide and pH of a liquid. The sensing electrode is an enhanced pH electrode separated from the measurement media by an electrolyte-filled chamber and gas permeable membrane. CO2 diffuses through the membrane and into the inner electrolyte of the dissolved carbon dioxide sensor, where it equilibrates with bicarbonate ions, altering the pH value. The relative change in pH value of the electrolyte is then measured by the enhanced pH electrode and correlated to the CO2 value.
For brewing, the InPro 5500i is a thermal conductivity CO2 sensor that provides reliable in-line measurement of dissolved carbon dioxide that can be directly integrated into the brewing or beverage production process.
METTLER TOLEDO produces a range of CO2 transmitters that can be used when building your measurement control loop. All of METTLER TOLEDO dissolved CO2 sensors are digital, and should therefore be integrated with an ISM transmitter.
